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In the remote Amazon, locals are saving a giant fish—and helping their villages  Project has brought income and electricity while protecting wide swaths of tropical forest Magic mushroom compound shows promise against cocaine addiction  Small study that prioritized Black and low-income participants yields “remarkable” results Competitive reactivity drives size- and composition-focusing in multimetallic nanocrystals | Science Multimetallic nanocrystals (NCs) offer distinctive properties driven by synergistic interactions among their constituent metals. Although colloidal chemistry enables control over size and composition, competing reactivities among metal precursors often ... Tuft dendrites in frontal motor cortex enable flexible learning | Science Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for action selection in rodents. We found that inputs ... Intermetallic nanoassemblies potentiate systemic STING activation | Science Natural systems use metal ions to form ordered structures that regulate biological processes, inspiring the rational design of nanotherapeutics. The cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of interferon genes (cGAS-... Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration | Science Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how short, specific RNAs solubilize TDP-43. These short RNAs ... Ferrimagnetism of ultracold fermions in a multiband Hubbard system | Science Strongly correlated materials feature multiple electronic orbitals, which are crucial to accurately understanding their many-body properties. In such multiband models, quantum interference can lead to flat energy bands with large degeneracy that gives ... In Other Journals | Science Editors’ selections from the current scientific literature In Science Journals | Science Highlights from the Science family of journals Knowledge gaps for neuromorphic ionic computing | Science Neuromorphic ionic computing is inspired by the brain’s use of ions for ultralow-energy computation—its massive parallelism, adaptability, and learning capabilities. This emerging paradigm can overcome limitations of conventional silicon-based computing ... Aging and the narrowing of scientific innovation | Science Aging researchers and the removal of retirement policies yield decreased disruptive innovation in science Safeguard water infrastructure amid conflict | Science Water infrastructure in conflict zones is vulnerable to deliberate kinetic strikes as well as the silent failure of maintenance and supply chains severed by war. When these systems collapse, the consequences cascade through public health and food security, exacerbating the vulnerabilities of regions already facing extreme climate stress. For example, recent attacks targeted desalination plants in Iran and Bahrain (1). In Ukraine and Gaza, the degradation of water and sanitation facilities routinely deprives millions of innocent civilians of safe drinking water, triggering resurgences of waterborne diseases and destabilizing hydrological basins (2, 3). International humanitarian law explicitly prohibits attacking objects indispensable to the survival of the civilian population, but enforcement remains elusive (4, 5). The vulnerability of Middle East desalination | Science In March, attacks on water infrastructure in Qeshm Island, Iran, and in Bahrain (1) drew attention to how quickly disruptions can threaten potable water supply in the Middle East. Across the Persian Gulf region and Israel, desalination supplies a dominant share of municipal drinking water. Centralized desalination plants enable economic growth and urbanization in some of the world’s most arid environments (2, 3) but make the region vulnerable to damage from geopolitical conflict (4). This risk highlights the need for Middle Eastern countries to strengthen the resilience of desalination infrastructure. Conflict imperils Middle East marine life | Science HomeScienceVol. 392, No. 6798Conflict imperils Middle East marine lifeBack To Vol. 392, No. 6798 Full accessLetter Share on Conflict imperils Middle East marine lifeHui Wang, Peng Liu, [...] , Lijuan Feng, and Ning Wang+1 authors fewerAuthors Info & AffiliationsScience7 May 2026Vol 392, Issue 6798p. 586DOI: 10.1126/science.aeh6024 PREVIOUS ARTICLEData-driven decisions in a fast-and-loose worldPre… Data-driven decisions in a fast-and-loose world | Science A journalist probes the history and future of evidence-based action Bury them in bureaucracy | Science Indigenous challenges to Spanish colonizers shaped Latin America in profound ways, argue two historians Building an oral peptide drug | Science Engineered enzymes enable kilogram-scale synthesis of drug for high-cholesterol conditions The future of plant extinction | Science Analyses of large-scale datasets call for urgent action to conserve plant diversity Delivering a STING to tumors | Science STING agonist nanoparticles trigger potent antitumor immunity in mice and rabbits Forecasting volcanic eruptions across scales | Science Predicting future volcanic eruptions requires better understanding of crustal magma storage Lessons in resistance from Tim Snyder | Science Federal grant cancellations, restrictions on immigration for foreign scientists, and attempts to cut the budgets of science funding agencies by 60%—the past 18 months have been tumultuous for American science. Even after Congress restored the budgets, ... AI agents may be skilled researchers—but not always honest ones  Two high-profile tools have been shown to make up data and “p-hack” their results CDC leader calls for new journal to ‘elevate scientific rigor’  Bhattacharya publicly slams vaccine study he pulled from agency’s flagship publication Chaotic whale rescue shocks marine biologists  Timmy, a humpback whale stranded in Germany 6 weeks ago, was ailing and may already be dead Deep-Earth map reveals a lost U.S. continent  Sensor array traces how rocks conduct electricity, exposing ancient continental fragments, mineral targets, and grid hazards Tiny probes make sense of abnormal bursts in the epileptic brain  “Spikes” hijack neurons involved in cognition—and can be predicted up to 1 second in advance Guns and bulletproof vests: How federal agents arrested Fauci aide  David Morens, 78, was stripped and handcuffed for email violations Human DHX29 detects nonoptimal codon usage to regulate mRNA stability | Science Synonymous codon usage controls global gene expression in both prokaryotic and eukaryotic species. Nonoptimal codons are known to induce messenger RNA (mRNA) decay; however, the underlying molecular mechanism remains poorly understood in human cells. ... A molecule with half-Möbius topology | Science Stereoisomers of C13Cl2 exhibiting helical orbitals around a ring of carbon atoms were synthesized by atom manipulation on NaCl surfaces. We resolved the enantiomeric geometries of the singlet states by atomic force microscopy and mapped their helical ... Rapid directed evolution guided by protein language models and epistatic interactions | Science Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking, whereas machine learning methods require extensive ...