Science Tue, 17 Mar 2026 04:10:36 +0000

Relic of long-vanished ice sheet holds clues to ancient climate  Glacial ice melting out of Alaska’s eroding coastline offers a glimpse into a lost climate history Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer | Science Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vitro and in vivo. We identified autophagolysosomal ... Lifelong behavioral screen reveals an architecture of vertebrate aging | Science Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behavioral tracking of the African killifish across natural ... Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | Science Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluorescent in situ hybridization (weMERFISH). We quantified ... Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis | Science Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the hemagglutinin gene was identified decades ago as the ... From field experiments to policy interventions at scale | Science A major advance in recent decades in the social sciences has been the use of field experiments for causal evaluation of policy interventions. Such interventions might be targeted to individuals, households, or communities, and have become commonplace in development and labor economics. This has built an enormous body of knowledge of ‘what works’ as well as an understanding of mechanisms underlying ‘why it works’. If an intervention is evaluated to enhance welfare and be cost effective, then the next challenge is to understand whether the intervention will generate similar benefits at scale. Recent work has been laying the foundation for thinking about the science of scaling and understanding why interventions can fail to scale. Strong and brittle lithium dendrites | Science The growth and penetration of lithium dendrites through electrolytes and separators remain key challenges to realizing high–energy density lithium-metal batteries. Using mechanically strong electrolytes and separators has been considered a promising ... In Other Journals | Science Editors’ selections from the current scientific literature In Science Journals | Science Highlights from the Science family of journals The fiscal impact of biodiversity loss and a pathway for conservation finance | Science Profit-seeking investors could align their muncipal bond investments with conservation actions Editor’s Note | Science The editors of Science are committed to humane and ethical use of animals in research. At a minimum, we require authors to meet the guidelines laid out in the US Animal Welfare Act. We also strongly encourage authors to meet the requirements of European Union Directive 210/63/EU, which is law in the United Kingdom and many European member states. European Union Directive 210/63/EU refers directly to the 3Rs (reduction, replacement, and refinement). These requirements have been posted on our “Science Journal: Editorial policies” page (1) for many years. Journals can help protect animal welfare—Response | Science We appreciate Carbone’s long-standing contributions to laboratory animal welfare and thank him for his thoughtful engagement with our study. Our experimental design was developed with explicit attention to refinement and necessity. Before the study began, the monkeys were trained for audiomotor synchronization by using standard primate neuroscience methods, which allow voluntary seating, postural comfort, and substantial freedom of movement, with only minimal restraint required to ensure task precision and safety. Hydration protocols were conservative, strictly and continuously monitored, and adjusted to maintain health and normal body weight. Journals can help protect animal welfare | Science The study described in the Research Article “Monkeys have rhythm” by V. G. Rajendran et al. (27 November 2025, 10.1126/science. adp5220) does not appropriately balance the harm done to laboratory animals against the potential benefits of the research. Science should raise the bar for animal welfare in the papers it publishes. The requirements for Rajendran et al.—to meet the minimal standards of the US Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals (1–3)—are insufficient. Antimicrobial resistance in India | Science Rejecting ignorance as the cause of antibiotic overuse, a pair of sociologists find more likely explanations The imminent collapse of the Great Salt Lake | Science A new documentary confronts the dire future of North America’s largest terminal lake KRAShing pancreatic cancer before takeoff | Science Drugs that inhibit KRAS signaling delay the development of pancreatic cancer in mice Extending the reach of a classic oncogene | Science Exocytosis exposes Src at the outer surface of cancer cells, poised for therapeutic targeting What’s the catch of the day? | Science Warming oceans and evolution make fish less likely to be on the menu Evolution to the rescue | Science Recovery of wildflower populations from extreme drought reveals hidden evolutionary resilience Releasing agriculture from the food security mandate | Science The state of food security is achieved if no one has to worry whether or how they can acquire—typically purchase—healthy and nutritious meals. In theory, food security could be addressed from two sides: increasing households’ purchasing power or lowering ... White House plan to break up iconic U.S. climate lab moves forward  Bidders have lined up to take over pieces of the National Center for Atmospheric Research NASA administrator talks to Science about studying the Moon, Mars—and Earth  Jared Isaacman says agency may accelerate lunar science program and could tackle a new Mars mission in 2028 U.S. agency will devote $144 million to studies that slow aging, extend quality of life  ARPA-H will “build the train tracks” for first large clinical studies of aging interventions New HIV cure approach forces hidden virus into tripping immune sensor  Strategy gains momentum after promising results in cell studies and infected people How will we know if AI is smart enough to do science?  New tests gauge whether large language models can use their deep troves of knowledge to actually make discoveries Programmable genome editing in human cells using RNA-guided bridge recombinases | Science Site-specific insertion of gene-sized DNA fragments remains an unmet need in the field of genome editing. IS110-family serine recombinases have recently been shown to mediate programmable DNA recombination in bacteria by using a bispecific RNA guide (... Computational design of conformation-biasing mutations to alter protein functions | Science Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational states. We successfully validated CB across seven diverse ... High-throughput single-cell omics using semipermeable capsules | Science Biological systems are inherently complex and heterogeneous. Deciphering this complexity increasingly relies on high-throughput single-cell omics methods and tools that efficiently probe the cellular phenotype and genotype. Here, we present a versatile ... Multistep genomics on single cells and live cultures in subnanoliter capsules | Science Single-cell sequencing methods uncover natural and induced variation between cells. Many functional genomic methods, however, require multiple steps that cannot yet be scaled to high throughput, including assays on living cells. In this study, we ... Megabase-scale human genome rearrangement with programmable bridge recombinases | Science Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study, we report the discovery and engineering of the bridge ...