Science Mon, 15 Sep 2025 19:41:21 +0000

Weird rings of DNA fuel cancers. This scientist leads the effort to target them  Paul Mischel and others are testing therapies for rogue genetic loops that drive tumor evolution and growth Structure and function of a huge photosystem I–fucoxanthin chlorophyll supercomplex from a coccolithophore | Science Photosystem I (PSI) is a pigment-protein complex, which converts light energy into chemical energy in photosynthesis. Among photosynthetic organisms, PSI-LHC (light-harvesting complex) structures exhibit substantial differences in their sizes, reflecting ... E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism | Science Transcription factors (TFs) may activate or repress gene expression through an interplay of different mechanisms, including RNA polymerase (RNAP) recruitment, exclusion, and initiation. However, depending on the regulated promoter identity, TF function ... Visual objects refine head direction coding | Science Animals use visual objects to guide navigation-related behaviors. However, visual object–preferring areas have yet to be described in the mouse brain, limiting our understanding of how visual objects affect spatial navigation system processing. Using ... Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana | Science Carbon fixation through the Calvin-Benson-Bassham (CBB) cycle accounts for the majority of carbon dioxide (CO2) uptake from the atmosphere. The CBB cycle generates C3 carbohydrates but is inefficient at producing acetyl–coenzyme A (CoA) (C2), which is ... Oxytocin signaling regulates maternally directed behavior during early life | Science Oxytocin is essential in shaping social behavior across the lifespan. Although the role of oxytocin signaling in parental care has been widely investigated, little is known about its function in social behavior during early life. We studied the role of ... Noncanonical circuits, states, and computations of the hippocampus | Science Traditional views of hippocampal function are largely based on the canonical flow of information from the entorhinal cortex through the trisynaptic loop—comprising the dentate gyrus and cornu ammonis regions CA3 and CA1—and back to cortex, where the ... An ELSI for AI: Learning from genetics to govern algorithms | Science In the United States, the summer of 2025 will be remembered as artificial intelligence’s (AI’s) cruel summer—a season when the unheeded risks and dangers of AI became undeniably clear. Recent months have made visible the stakes of the unchecked use of AI:... A main-group metal carbonyl complex: Structure and isomerization to a carbene-stabilized tin atom | Science In contrast to transition elements, s- and p-block metal compounds that coordinate carbon monoxide (CO) under near-ambient conditions are elusive. Here, we report an isolable, crystalline main-group metal carbonyl complex and its isomerization to a ... Structural basis for LZTR1 recognition of RAS GTPases for degradation | Science The RAS family of small guanosine triphosphatases (GTPases) are tightly regulated signaling molecules that are further modulated by ubiquitination and proteolysis. Leucine Zipper-like Transcription Regulator 1 (LZTR1), a substrate adapter of the Cullin-3 ... In Other Journals | Science Editors’ selections from the current scientific literature In Science Journals | Science Highlights from the Science family of journals Include scorpions in global conservation plans | Science HomeScienceVol. 389, No. 6765Include scorpions in global conservation plansBack To Vol. 389, No. 6765 Full accessLetter Share on Include scorpions in global conservation plansJavier Blasco-Aróstegui, Jairo A. Moreno-González, [...] , Stephanie F. Loria, Leonardo S. Carvalho, [...] , Tharina L. Bird, Ahn D. Nguyen, Hossein Barahoei, Charles R. Haddad, and Lorenzo Prendini+6 authors +4 authors fewe… Safe food: A human right amid climate change | Science Unsafe food leads to illness in an estimated 600 million people and causes 420,000 deaths globally each year (1, 2). Foodborne illness and death disproportionately affect children under the age of 5 and people in low-income countries (1). Access to safe and nutritious food is included in the United Nations (UN) Sustainable Development Goals as target 2.1, but food safety is often overlooked in many national adaptation plans (3, 4). The right to adequate food is globally recognized, but access to safe food is not explicitly guaranteed (5, 6). Given that access to safe food is critical to equitable and sustainable food systems and that climate change will exacerbate the likelihood of foodborne illnesses and deaths (2), the global community must explicitly enshrine food safety as a universal human right. Bolivia must prioritize biodiversity | Science HomeScienceVol. 389, No. 6765Bolivia must prioritize biodiversityBack To Vol. 389, No. 6765 Full accessLetter Share on Bolivia must prioritize biodiversityOswaldo MaillardAuthors Info & AffiliationsScience11 Sep 2025Vol 389, Issue 6765p. 1098DOI: 10.1126/science.adz6251 PREVIOUS ARTICLEBehind the scenes of scientific fraudPreviousNEXT ARTICLESafe food: A human right amid climate changeNext Notif… Behind the scenes of scientific fraud | Science A coauthor on a paper with fabricated data reckons with the fallout Restoring trust in science | Science A pair of authors offer a “battle plan” for combating antiscience sentiment The precarious future of consumer genetic privacy | Science Congress and other lawmakers must act to robustly protect direct-to-consumer genetic data and biospecimens into the future Illusions of AI consciousness | Science The belief that AI is conscious is not without risk Cries into ties | Science Oxytocin neurons in mouse pups regulate vocalization to maintain maternal bonds Gene flow stops sooner in plants than in animals | Science Genomic data indicate when species became reproductively isolated Burning questions on wildfire | Science Fire heat may change how wildfire affects air pollution in the United States Unburden American science | Science Science is one of the greatest engines of health, prosperity, and security across the world. Yet, in the United States, the enterprise is now under tremendous stress from an array of pressures, including threats to federal support for both the direct and ... Great Britain’s economy didn’t completely tank after Romans left, countering conventional wisdom  “Completely surprising” discovery based on ancient pollutants suggests mining and smelting continued apace for centuries Strongest black hole collision yet confirms theories of Einstein, Hawking  Observation confirms that a black hole’s area can only grow and never shrink Florida plans to nix vaccine mandates. How well do they work?  Abandoning long-standing vaccine requirements for schoolchildren could prompt bigger outbreaks, researchers warn Harvard victory leaves scientists feeling vindicated but uncertain  Trump administration vows to appeal ruling that it illegally cut $2.2 billion in research funding Mosquito-borne viruses surge in a warming Europe  Chikungunya cases break records in France; West Nile virus appears near Rome Data from defunct NASA lander paint a radical new picture of Mars’s interior  Studies identify a solid inner core and buried remnants of giant impacts Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex | Science Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and Pfs48/45 proteins are critical for male fertility and ...