Science Fri, 22 Aug 2025 23:40:51 +0000

Driven by the pain of endometriosis, this scientist is uncovering clues to its causes  Katie Burns is helping reveal the immune system’s role in the long-neglected disease DNA from ancient bones reveals how Indigenous Americans got their mucus  Neanderthals and Denisovans passed along gene that provides a sticky shield against germs LYVAC/PDZD8 is a lysosomal vacuolator | Science Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anchored lipid transfer protein PDZ domain–containing 8 (... Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays | Science Single-cell sequencing technologies have advanced our understanding of cellular heterogeneity and biological complexity. However, existing methods face limitations in throughput, capture uniformity, cell size flexibility, and technical extensibility. We ... The MUC19 gene: An evolutionary history of recurrent introgression and natural selection | Science We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants for the Denisovan-like MUC19 haplotype at high ... Load and lock: An emerging class of therapeutics that influence macromolecular dissociation | Science Biology is governed by macromolecular interactions, perturbation of which often lies at the heart of disease. Most therapeutic drugs, whether they are small molecules or biologics, exert their effects through impeding such interactions, whether they are ... Disability and AI: Much more than assistive technologies | Science Nothing succeeds like success, we are told, and certainly that seems true for artificial intelligence (AI). It is hard to overstate either the ubiquity or the success of AI-based technologies in science and technology, health research and care, the media,... Ultracompact on-chip spectral shaping using pixelated nano-opto-electro-mechanical gratings | Science The ability to shape light spectra dynamically and arbitrarily would revolutionize many photonic systems by offering unparalleled spectral efficiency and network flexibility. However, most existing optical components have rigid spectral functionalities ... Universal coarsening in a homogeneous two-dimensional Bose gas | Science Coarsening of an isolated far-from-equilibrium quantum system is a paradigmatic many-body phenomenon, relevant from subnuclear to cosmological length scales and predicted to feature universal dynamic scaling. Here, we observed universal scaling in the ... In Other Journals | Science Editors’ selections from the current scientific literature In Science Journals | Science Highlights from the Science family of journals Brazilian policy weakens shark conservation | Science In April, Brazil’s Ministries of Fisheries & Aquaculture and Environment enacted Interministerial Ordinance No. 30 authorizing targeted fishing of the blue shark (Prionace glauca) across national and international waters (1). Although presented as a sustainable fisheries measure, the ordinance substantially weakens shark conservation and contradicts Brazil’s international commitments under the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) (2). The Brazilian government should reevaluate this ordinance through a transparent, science-based process and expedite shark conservation measures. Pakistan’s reptiles need protection | Science Pakistan is home to about 195 reptile species (1). Reptiles are crucial components of ecological systems, acting as both prey and predators. They contribute to the regulation of pest populations, facilitate nutrient cycling, and support energy transmission across trophic levels, thereby ensuring ecosystem stability (2). Globally, reptiles declined 69% between 1970 and 2018 (3), but no long-term monitoring data on reptile populations in Pakistan exist (4). To conserve its reptile fauna, Pakistan needs to implement targeted studies to assess undocumented declines and to mitigate known threats to their populations and habitats (1). Yarmouk Treaty could ease Jordan’s water crisis | Science HomeScienceVol. 389, No. 6762Yarmouk Treaty could ease Jordan’s water crisisBack To Vol. 389, No. 6762 Full accessLetter Share on Yarmouk Treaty could ease Jordan’s water crisisHussam HusseinAuthors Info & AffiliationsScience21 Aug 2025Vol 389, Issue 6762p. 789DOI: 10.1126/science.ady5453 PREVIOUS ARTICLEDiscovering DenisovaPreviousNEXT ARTICLEPakistan’s reptiles need protectionNext Notification… Discovering Denisova | Science A pair of authors invite readers to get to know the elusive archaic human Mutualism—here, there, and everywhere | Science A biologist finds wisdom in nature’s reciprocal partnerships Disrupting the biospecimen “treasure trove”: Practice, precedent, and future directions | Science Decentralized biobanking can reconnect individuals to their specimens, democratizing data ownership A protein tunnel helps stressed lysosomes swell | Science The endoplasmic reticulum donates lipids through a tunnel-like protein to help lysosomes expand Outshining molecular disorder with light | Science Experiments quantify an important criterion for polariton-mediated energy transport Ripple bug robots demonstrate interfacial intelligence | Science Insect and robot appendages are autonomously controlled by the air-water interface A shared circuit might link depression and anxiety | Science Loss of motivation and heightened sensitivity to threat are driven by a network of overlapping brain regions Rewiring science diplomacy | Science Over the past two decades, science diplomacy has been cast in a glow of hopeful optimism, especially by academics. It was framed as the art of bridge building, opening channels between adversaries, a common language across cultures, and a refuge for ... Neutrino astronomers set biggest traps ever for messengers from cosmic accelerators  Country-size array of radio antennas could trace ultra–high-energy particles back to supernovae and black holes Facing ‘impossible’ workload, USDA struggles to oversee lab animal welfare  Shrinking staff and other handicaps threaten enforcement of federal law that protects research animals As salmon in Alaska plummet, scientists home in on a killer  Chinook in the Yukon River appear to be particularly vulnerable to a common parasite—and warming waters may be abetting the infection Don’t blame the algorithm: Polarization may be inherent in social media  In simulations, AI-generated users of stripped-down social media without content algorithms still split into polarized echo chambers Hot springs’ hardy microbes offer new source of antibiotics  The mysterious branch of life of known as archaea harbor unique bacteria-fighting compounds Recent evolution of the developing human intestine affects metabolic and barrier functions | Science Diet, microbiota, and other exposures make the intestinal epithelium a nexus for evolutionary change; however, little is known about genomic changes associated with adaptation to a distinctly human environment. In this work, we interrogate the evolution ... Disassembly activates Retron-Septu for antiphage defense | Science Retrons are antiphage defense systems that produce multicopy single-stranded DNA (msDNA) and hold promise for genome engineering. However, the mechanisms of defense remain unclear. The Retron-Septu system integrates retron and Septu antiphage defenses. ...